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Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy.

ABSTRACT: Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5-15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.

SUBMITTER: Shih YH

PROVIDER: S-EPMC6627879 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy.

Shih Yin-Hwa YH Wang Tong-Hong TH Shieh Tzong-Ming TM Tseng Yu-Hsin YH

International journal of molecular sciences 20190616 12

Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5-15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and th ...[more]

PMID: 31208114

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Treatment outcomes of laser therapy in oral submucous fibrosis-a systematic review.

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| S-EPMC7264056 | biostudies-literature

Polyphenol-based targeted therapy for oral submucous fibrosis.

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Project description: Not available

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Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis.

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2021-07-24 | GSE156669 | GEO

PTMA, a new identified autoantigen for oral submucous fibrosis, regulates oral submucous fibroblast proliferation and extracellular matrix.

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LINC00312/YBX1 Axis Regulates Myofibroblast Activities in Oral Submucous Fibrosis.

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