Ontology highlight
ABSTRACT:
SUBMITTER: Rivera-Paredez B
PROVIDER: S-EPMC6627998 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Rivera-Paredez Berenice B Macías-Kauffer Luis L Fernandez-Lopez Juan Carlos JC Villalobos-Comparán Marisela M Martinez-Aguilar Mayeli M MM de la Cruz-Montoya Aldo A Ramírez-Salazar Eric G EG Villamil-Ramírez Hugo H Quiterio Manuel M Ramírez-Palacios Paula P Romero-Hidalgo Sandra S Villarreal-Molina María Teresa MT Denova-Gutiérrez Edgar E Flores Yvonne N YN Canizales-Quinteros Samuel S Salmerón Jorge J Velázquez-Cruz Rafael R
Nutrients 20190614 6
Risk of hyperuricemia is modified by genetic and environmental factors. Our aim was to identify factors associated with serum uric acid levels and hyperuricemia in Mexicans. A pilot Genome-wide association study GWAS was performed in a subgroup of participants (<i>n</i> = 411) from the Health Workers Cohort Study (HWCS). Single nucleotide polymorphisms (SNPs) associated with serum uric acid levels were validated in all the HWCS participants (<i>n</i> = 1939) and replicated in independent childre ...[more]