Ontology highlight
ABSTRACT:
SUBMITTER: Kunkl M
PROVIDER: S-EPMC6628233 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kunkl Martina M Sambucci Manolo M Ruggieri Serena S Amormino Carola C Tortorella Carla C Gasperini Claudio C Battistini Luca L Tuosto Loretta L
Cells 20190611 6
The immunopathogenesis of multiple sclerosis (MS) depend on the expansion of specific inflammatory T cell subsets, which are key effectors of tissue damage and demyelination. Emerging studies evidence that a reprogramming of T cell metabolism may occur in MS, thus the identification of stimulatory molecules and associated signaling pathways coordinating the metabolic processes that amplify T cell inflammation in MS is pivotal. Here, we characterized the involvement of the cluster of differentiat ...[more]