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A TLR-inducible Cyclin J regulates inflammatory and anti-tumor responses by suppressing macrophage glycolysis via CDKs

ABSTRACT: Proteome and phosphoproteome analyses were performed to identify CDK substrates whose phosphorylation is induced by Cyclin J in macrophages. In the first experiment, RAW264.7 cells synchronized in G2/M phase by Nocodazole were treated with CDK inhibitors, Flavopiridol or Roscovitine, followed by phosphoproteomics. In the second experiment, proteome and phosphoproteome analyses were performed to characterize RAW264.7 cells inducibly expressing Cyclin J.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Osamu Takeuchi

PROVIDER: PXD021176 | JPOST Repository | Sat Aug 28 00:00:00 BST 2021

REPOSITORIES: jPOST

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			Action	DRS
	Phosphoproteomics_RAW264.7_CDK%20inhibitors.txt	Txt
	Phosphoproteomics_RAW264.7_CDK%20inhibitors_fr1.raw	Raw
	Phosphoproteomics_RAW264.7_CDK%20inhibitors_fr2.raw	Raw
	Phosphoproteomics_RAW264.7_CDK%20inhibitors_fr3.raw	Raw
	Phosphoproteomics_RAW264.7_CDK%20inhibitors_fr4.raw	Raw

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