A Review of the Role of Wnt in Cancer Immunomodulation.
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ABSTRACT:
SUBMITTER: Goldsberry WN
PROVIDER: S-EPMC6628296 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
A Review of the Role of Wnt in Cancer Immunomodulation.
Goldsberry Whitney N WN Londoño Angelina A Randall Troy D TD Norian Lyse A LA Arend Rebecca C RC
Cancers 20190604 6
Alterations in the Wnt signaling pathway are associated with the advancement of cancers; however, the exact mechanisms responsible remain largely unknown. It has recently been established that heightened intratumoral Wnt signaling correlates with tumor immunomodulation and immune suppression, which likely contribute to the decreased efficacy of multiple cancer therapeutics. Here, we review available literature pertaining to connections between Wnt pathway activation in the tumor microenvironment ...[more]
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