5',8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance.
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ABSTRACT:
SUBMITTER: Chatgilialoglu C
PROVIDER: S-EPMC6628319 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
5',8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance.
Chatgilialoglu Chryssostomos C Ferreri Carla C Geacintov Nicholas E NE Krokidis Marios G MG Liu Yuan Y Masi Annalisa A Shafirovich Vladimir V Terzidis Michael A MA Tsegay Pawlos S PS
Cells 20190528 6
Purine 5',8-cyclo-2'-deoxynucleosides (cPu) are tandem-type lesions observed among the DNA purine modifications and identified in mammalian cellular DNA in vivo. These lesions can be present in two diasteroisomeric forms, 5'<i>R</i> and 5'<i>S</i>, for each 2'-deoxyadenosine and 2'-deoxyguanosine moiety. They are generated exclusively by hydroxyl radical attack to 2'-deoxyribose units generating C5' radicals, followed by cyclization with the C8 position of the purine base. This review describes ...[more]
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