Ontology highlight
ABSTRACT:
SUBMITTER: Lee JS
PROVIDER: S-EPMC6629081 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lee Ji Soo JS Lee Yeunkum Y André Emily A EA Lee Kea Joo KJ Nguyen Thien T Feng Yang Y Jia Nuo N Harris Brent T BT Burns Mark P MP Pak Daniel T S DTS
PloS one 20190715 7
Alzheimer disease (AD) is a neurodegenerative disorder characterized by pathological hallmarks of neurofibrillary tangles and amyloid plaques. The plaques are formed by aggregation and accumulation of amyloid β (Aβ), a cleavage fragment of amyloid precursor protein (APP). Enhanced neuronal activity and seizure events are frequently observed in AD, and elevated synaptic activity promotes Aβ production. However, the mechanisms that link synaptic hyperactivity to APP processing and AD pathogenesis ...[more]