Ontology highlight
ABSTRACT:
SUBMITTER: Vinke P
PROVIDER: S-EPMC6629640 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Vinke Paulien P Bowen T Scott TS Boekschoten Mark V MV Witkamp Renger F RF Adams Volker V van Norren Klaske K
Scientific reports 20190715 1
Pulmonary arterial hypertension (PAH) is characterized by remodelling of the pulmonary arteries and right ventricle (RV), which leads to functional decline of cardiac and skeletal muscle. This study investigated the effects of a multi-targeted nutritional intervention with extra protein, leucine, fish oil and oligosaccharides on cardiac and skeletal muscle in PAH. PAH was induced in female C57BL/6 mice by weekly injections of monocrotaline (MCT) for 8 weeks. Control diet (sham and MCT group) and ...[more]