Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies.
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ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC6629651 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies.
Luo Xiangyu X Yang Can C Wei Yingying Y
Nature communications 20190715 1
In epigenome-wide association studies, the measured signals for each sample are a mixture of methylation profiles from different cell types. Current approaches to the association detection claim whether a cytosine-phosphate-guanine (CpG) site is associated with the phenotype or not at aggregate level and can suffer from low statistical power. Here, we propose a statistical method, HIgh REsolution (HIRE), which not only improves the power of association detection at aggregate level as compared to ...[more]
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