Landscape of transcriptomic interactions between breast cancer and its microenvironment.
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ABSTRACT:
SUBMITTER: Fox NS
PROVIDER: S-EPMC6629667 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Landscape of transcriptomic interactions between breast cancer and its microenvironment.
Fox Natalie S NS Haider Syed S Harris Adrian L AL Boutros Paul C PC
Nature communications 20190715 1
Solid tumours comprise mixtures of tumour cells (TCs) and tumour-adjacent cells (TACs), and the intricate interconnections between these diverse populations shape the tumour's microenvironment. Despite this complexity, clinical genomic profiling is typically performed from bulk samples, without distinguishing TCs from TACs. To better understand TC-TAC interactions, we computationally distinguish their transcriptomes in 1780 primary breast tumours. We show that TC and TAC mRNA abundances are dive ...[more]
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