Transcriptomic landscape of breast cancers through mRNA sequencing.
Ontology highlight
ABSTRACT:
SUBMITTER: Eswaran J
PROVIDER: S-EPMC3278922 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Transcriptomic landscape of breast cancers through mRNA sequencing.
Eswaran Jeyanthy J Cyanam Dinesh D Mudvari Prakriti P Reddy Sirigiri Divijendra Natha SD Pakala Suresh B SB Nair Sujit S SS Florea Liliana L Fuqua Suzanne A W SA Godbole Sucheta S Kumar Rakesh R
Scientific reports 20120214
Breast cancer is a heterogeneous disease with a poorly defined genetic landscape, which poses a major challenge in diagnosis and treatment. By massively parallel mRNA sequencing, we obtained 1.2 billion reads from 17 individual human tissues belonging to TNBC, Non-TNBC, and HER2-positive breast cancers and defined their comprehensive digital transcriptome for the first time. Surprisingly, we identified a high number of novel and unannotated transcripts, revealing the global breast cancer transcr ...[more]
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