Dataset Information

Facile Synthesis of MnO₂ Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid.

ABSTRACT: This study reports facile synthesis of MnO₂ nanoflowers/N-doped reduced graphene oxide (MnO₂NFs/NrGO) composite and its application on the simultaneous determination of dopamine (DA) and uric acid (UA). The microstructures, morphologies, and electrochemical performances of MnO₂NFs/NrGO were studied using X-ray diffraction (XRD), scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS), respectively. The electrochemical experiments showed that the MnO₂NFs/NrGO composites have the largest effective electroactive area and lowest charge transfer resistance. MnO₂NFs/NrGO nanocomposites displayed superior catalytic capacity toward the electro-oxidation of DA and UA due to the synergistic effect from MnO₂NFs and NrGO. The anodic peak currents of DA and UA increase linearly with their concentrations varying from 0.2 ?M to 6.0 ?M. However, the anodic peak currents of DA and UA are highly correlated to the Napierian logarithm of their concentrations ranging from 6.0 ?M to 100 ?M. The detection limits are 0.036 ?M and 0.029 ?M for DA and UA, respectively. Furthermore, the DA and UA levels of human serum samples were accurately detected by the proposed sensor. Combining with prominent advantages such as facile preparation, good sensitivity, and high selectivity, the proposed MnO₂NFs/NrGO nanocomposites have become the most promising candidates for the simultaneous determination of DA and UA from various actual samples.

SUBMITTER: Wan X

PROVIDER: S-EPMC6631201 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Facile Synthesis of MnO2 Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid.

Wan Xuan X Yang Shihui S Cai Zhaotian Z He Quanguo Q Ye Yabing Y Xia Yonghui Y Li Guangli G Liu Jun J

Nanomaterials (Basel, Switzerland) 20190602 6

This study reports facile synthesis of MnO2 nanoflowers/N-doped reduced graphene oxide (MnO2NFs/NrGO) composite and its application on the simultaneous determination of dopamine (DA) and uric acid (UA). The microstructures, morphologies, and electrochemical performances of MnO2NFs/NrGO were studied using X-ray diffraction (XRD), scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS), respectively. The electro ...[more]

PMID: 31159490

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Project description:Using a simple drop-casting technique, we successfully fabricated a sensitive electrochemical sensor based on the composite of reduced graphene oxide (RGO) and multiwalled carbon nanotubes (MWCNT) deposited on the surface of a glassy carbon electrode (GCE) for individual and simultaneous measurements of hydroquinone (HQ), dopamine (DA), and uric acid (UA). The nanocomposite of RGO/MWCNT was further characterized in terms of its structural properties, surface morphology, and topography using Raman, FT-IR spectroscopy, SEM, HRTEM, and AFM. Then, the proposed sensor for simultaneous measurement of HQ, DA, and UA based on RGO/MWCNT-modified GCE was investigated for its electrochemical behavior and electroanalytical performances using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). In addition, the composition ratio between RGO and MWCT was 1 : 1 showing the highest electrochemical response for simultaneous detection of HQ, DA, and UA. Owing to the synergistic effect between RGO and MWCNT leading to excellent conductivity properties, the proposed sensor exhibited improved electrochemical response at pH 7 toward the oxidation processes of HQ, DA, and UA on the surface of modified electrode. The proposed sensor demonstrated three well-defined anodic peaks of these analytes with their linear concentrations ranges of 3.0-150.0 μM for HQ, 4.0-100.0 μM for DA, and 2.0-70.0 μM for UA. The limit of detection values for the simultaneous detection of HQ, DA, and UA were found as follows 0.400 ± 0.014, 0.500 ± 0.006, and 0.300 ± 0.016 μM, respectively. The additional features of this proposed sensor are high reproducibility and stability for the simultaneous detection of HQ, DA, and UA with negligible interference effect from interferents such as Mg2+, K+, Cl-, ascorbic acid, and glucose. An acceptable percentage of recovery was also shown by this sensor for simultaneous measurements of HQ, DA, and UA using 6 samples of human urine. In summary, the RGO/MWCNT nanocomposite has been shown to be a promising platform for rapid, simple, and reliable determination of simultaneous measurements of HQ, DA, and UA in practical applications.

Dataset Information

Facile Synthesis of MnO₂ Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid.

Publications

Facile Synthesis of MnO<sub>2</sub> Nanoflowers/N-Doped Reduced Graphene Oxide Composite and Its Application for Simultaneous Determination of Dopamine and Uric Acid.

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