Ontology highlight
ABSTRACT:
SUBMITTER: Atkinson-Leadbeater K
PROVIDER: S-EPMC6633001 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Atkinson-Leadbeater Karen K Bertolesi Gabriel E GE Hehr Carrie L CL Webber Christine A CA Cechmanek Paula B PB McFarlane Sarah S
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100101 2
Axons are guided to their targets by molecular cues expressed in their environment. How is the presence of these cues regulated? Although some evidence indicates that morphogens establish guidance cue expression as part of their role in patterning tissues, an important question is whether morphogens are then required to maintain guidance signals. We found that fibroblast growth factor (FGF) signaling sustains the expression of two guidance cues, semaphorin3A (xsema3A) and slit1 (xslit1), through ...[more]