Axon guidance by growth-rate modulation.
Ontology highlight
ABSTRACT:
SUBMITTER: Mortimer D
PROVIDER: S-EPMC2841880 | biostudies-other | 2010 Mar
REPOSITORIES: biostudies-other
Publications
Axon guidance by growth-rate modulation.
Mortimer Duncan D Pujic Zac Z Vaughan Timothy T Thompson Andrew W AW Feldner Julia J Vetter Irina I Goodhill Geoffrey J GJ
Proceedings of the National Academy of Sciences of the United States of America 20100301 11
Guidance of axons by molecular gradients is crucial for wiring up the developing nervous system. It often is assumed that the unique signature of such guidance is immediate and biased turning of the axon tip toward or away from the gradient. However, here we show that such turning is not required for guidance. Rather, by a combination of experimental and computational analyses, we demonstrate that growth-rate modulation is an alternative mechanism for guidance. Furthermore we show that, although ...[more]
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