Ontology highlight
ABSTRACT:
SUBMITTER: Piccoli G
PROVIDER: S-EPMC6633036 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Piccoli Giovanni G Condliffe Steven B SB Bauer Matthias M Giesert Florian F Boldt Karsten K De Astis Silvia S Meixner Andrea A Sarioglu Hakan H Vogt-Weisenhorn Daniela M DM Wurst Wolfgang W Gloeckner Christian Johannes CJ Matteoli Michela M Sala Carlo C Ueffing Marius M
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110201 6
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson's disease. Little is known about its involvement in the pathogenesis of Parkinson's disease mainly because of the lack of knowledge about the physiological role of LRRK2. To determine the function of LRRK2, we studied the impact of short hairpin RNA-mediated silencing of LRRK2 expression in cortical neurons. Paired recording indicated that LRRK2 silencing affects evoked postsynaptic currents ...[more]