Ontology highlight
ABSTRACT:
SUBMITTER: Jager M
PROVIDER: S-EPMC6633256 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Jager Myrthe M Blokzijl Francis F Kuijk Ewart E Bertl Johanna J Vougioukalaki Maria M Janssen Roel R Besselink Nicolle N Boymans Sander S de Ligt Joep J Pedersen Jakob Skou JS Hoeijmakers Jan J Pothof Joris J van Boxtel Ruben R Cuppen Edwin E
Genome research 20190620 7
Nucleotide excision repair (NER) is one of the main DNA repair pathways that protect cells against genomic damage. Disruption of this pathway can contribute to the development of cancer and accelerate aging. Mutational characteristics of NER-deficiency may reveal important diagnostic opportunities, as tumors deficient in NER are more sensitive to certain treatments. Here, we analyzed the genome-wide somatic mutational profiles of adult stem cells (ASCs) from NER-deficient <i>Ercc1</i> <sup>-/Δ</ ...[more]