Ontology highlight
ABSTRACT:
SUBMITTER: Vejnar CE
PROVIDER: S-EPMC6633259 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Vejnar Charles E CE Abdel Messih Mario M Takacs Carter M CM Yartseva Valeria V Oikonomou Panos P Christiano Romain R Stoeckius Marlon M Lau Stephanie S Lee Miler T MT Beaudoin Jean-Denis JD Musaev Damir D Darwich-Codore Hiba H Walther Tobias C TC Tavazoie Saeed S Cifuentes Daniel D Giraldez Antonio J AJ
Genome research 20190621 7
Posttranscriptional regulation plays a crucial role in shaping gene expression. During the maternal-to-zygotic transition (MZT), thousands of maternal transcripts are regulated. However, how different <i>cis</i>-elements and <i>trans</i>-factors are integrated to determine mRNA stability remains poorly understood. Here, we show that most transcripts are under combinatorial regulation by multiple decay pathways during zebrafish MZT. By using a massively parallel reporter assay, we identified <i>c ...[more]