Nitrosative stress drives heart failure with preserved ejection fraction.
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ABSTRACT:
SUBMITTER: Schiattarella GG
PROVIDER: S-EPMC6635957 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Nitrosative stress drives heart failure with preserved ejection fraction.
Schiattarella Gabriele G GG Altamirano Francisco F Tong Dan D French Kristin M KM Villalobos Elisa E Kim Soo Young SY Luo Xiang X Jiang Nan N May Herman I HI Wang Zhao V ZV Hill Theodore M TM Mammen Pradeep P A PPA Huang Jian J Lee Dong I DI Hahn Virginia S VS Sharma Kavita K Kass David A DA Lavandero Sergio S Gillette Thomas G TG Hill Joseph A JA
Nature 20190410 7752
Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high morbidity and mortality for which there are no evidence-based therapies. Here we report that concomitant metabolic and hypertensive stress in mice-elicited by a combination of high-fat diet and inhibition of constitutive nitric oxide synthase using N<sup>ω</sup>-nitro-L-arginine methyl ester (L-NAME)-recapitulates the numerous systemic and cardiovascular features of HFpEF in humans. Expression of one of the unf ...[more]
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