Ontology highlight
ABSTRACT:
SUBMITTER: Tao Y
PROVIDER: S-EPMC6636642 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Cancer cell 20190201 2
We addressed the precursor role of aging-like spontaneous promoter DNA hypermethylation in initiating tumorigenesis. Using mouse colon-derived organoids, we show that promoter hypermethylation spontaneously arises in cells mimicking the human aging-like phenotype. The silenced genes activate the Wnt pathway, causing a stem-like state and differentiation defects. These changes render aged organoids profoundly more sensitive than young ones to transformation by Braf<sup>V600E</sup>, producing the ...[more]