Ontology highlight
ABSTRACT:
SUBMITTER: Lee K
PROVIDER: S-EPMC6636862 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Lee Kihyun K Cho Hyunwoo H Rickert Robert W RW Li Qing V QV Pulecio Julian J Leslie Christina S CS Huangfu Danwei D
Cell reports 20190701 2
Transcriptional regulatory mechanisms of lineage priming in embryonic development are largely uncharacterized because of the difficulty of isolating transient progenitor populations. Directed differentiation of human pluripotent stem cells (hPSCs) combined with gene editing provides a powerful system to define precise temporal gene requirements for progressive chromatin changes during cell fate transitions. Here, we map the dynamic chromatin landscape associated with sequential stages of pancrea ...[more]