Ontology highlight
ABSTRACT:
SUBMITTER: Halder S
PROVIDER: S-EPMC6637133 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Halder Swagata S Torrecilla Ignacio I Burkhalter Martin D MD Popović Marta M Fielden John J Vaz Bruno B Oehler Judith J Pilger Domenic D Lessel Davor D Wiseman Katherine K Singh Abhay Narayan AN Vendrell Iolanda I Fischer Roman R Philipp Melanie M Ramadan Kristijan K
Nature communications 20190717 1
The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA replication in vertebrate cells. Cells deficient in SPRTN protease exhibit DPC-induced replication stress and genome instability, manifesting as premature ageing and liver cancer. Here, we provide a body of evidence suggesting that SPRTN activates the ATR-CHK1 phosphorylation signalling cascade during physiological DNA replication by proteolysis-dependent eviction of CHK1 from replicative chromatin. During this ...[more]