Ontology highlight
ABSTRACT:
SUBMITTER: Na J
PROVIDER: S-EPMC7870818 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Na Juri J Newman Joseph A JA Then Chee Kin CK Syed Junetha J Vendrell Iolanda I Torrecilla Ignacio I Ellermann Sophie S Ramadan Kristijan K Fischer Roman R Kiltie Anne E AE
Cell death & disease 20210208 2
The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3'-5' exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C-terminally truncated form of MRE11 (TR-MRE11) associated with post-translational MRE11 degradation. Here we identified SPRTN as the essential protease for the formation of TR-MRE11 and characterised the role of this MRE11 form in its DNA damage response ( ...[more]