Establishment and equilibrium levels of deleterious mutations in large populations.

ABSTRACT: Analytical and statistical stochastic approaches are used to model the dispersion of monogenic variants through large populations. These approaches are used to quantify the magnitude of the selective advantage of a monogenic heterozygous variant in the presence of a homozygous disadvantage. Dunbar's results regarding the cognitive upper limit of the number of stable social relationships that humans can maintain are used to determine a realistic effective community size from which an individual can select mates. By envisaging human community structure as a network where social proximity rather than physical geography predominates, a significant simplification is achieved, implicitly accounting for the effects of migration and consanguinity, and with population structure and genetic drift be

SUBMITTER: Viljoen JW 

PROVIDER: S-EPMC6637196 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature