Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum.
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SUBMITTER: Ross LS
PROVIDER: S-EPMC6639022 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum.
Ross Leila S LS Fidock David A DA
Cell host & microbe 20190701 1
Intensified treatment and control efforts since the early 2000s have dramatically reduced the burden of Plasmodium falciparum malaria. However, drug resistance threatens to derail this progress. In this review, we present four antimalarial resistance case studies that differ in timeline, technical approaches, mechanisms of action, and categories of resistance: chloroquine, sulfadoxine-pyrimethamine, artemisinin, and piperaquine. Lessons learned from prior losses of treatment efficacy, drug combi ...[more]
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