Ontology highlight
ABSTRACT:
SUBMITTER: Boase NA
PROVIDER: S-EPMC6639052 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Boase Natasha Anne NA Kumar Sharad S
Gene 20141217 2
Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. In this review we will discuss the diverse pathways ...[more]