Ontology highlight
ABSTRACT:
SUBMITTER: Koshizuka T
PROVIDER: S-EPMC5849660 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20180313 1
Nedd4 is a family of ubiquitin E3 ligases that regulate numerous cellular processes. In this report, we showed that alpha- and beta-herpesviruses have membrane proteins that regulate the function of the Nedd4 family members. Although the homology search score was quite low, UL56 of herpes simplex virus type 1 and 2, ORF0 of varicella-zoster virus, UL42 of human cytomegalovirus, and U24 of human herpesvirus 6A, 6B, and 7 all possess at least one PPxY (PY) motif in their cytoplasmic domain, and ar ...[more]