Ontology highlight
ABSTRACT:
SUBMITTER: Gannon AL
PROVIDER: S-EPMC6639311 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Gannon Anne-Louise AL O'Hara Laura L Mason J Ian JI Jørgensen Anne A Frederiksen Hanne H Milne Laura L Smith Sarah S Mitchell Rod T RT Smith Lee B LB
Scientific reports 20190718 1
Androgens are known to be an essential regulator of male health. Androgen receptor (AR) is widely expressed throughout the adrenal cortex, yet the wider role for androgen signalling in the adrenal remains underexplored. To investigate AR-dependent and AR-independent androgen signalling in the adrenal, we used a novel mouse model with a specific ablation of androgen receptor in the adrenal cortex with or without reduction of circulating androgen levels by castration. Our results describe AR expre ...[more]