ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration.
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ABSTRACT:
SUBMITTER: Muliyil S
PROVIDER: S-EPMC7459420 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration.
Muliyil Sonia S Levet Clémence C Düsterhöft Stefan S Dulloo Iqbal I Cowley Sally A SA Freeman Matthew M
The EMBO journal 20200726 17
Animals have evolved multiple mechanisms to protect themselves from the cumulative effects of age-related cellular damage. Here, we reveal an unexpected link between the TNF (tumour necrosis factor) inflammatory pathway, triggered by the metalloprotease ADAM17/TACE, and a lipid droplet (LD)-mediated mechanism of protecting retinal cells from age-related degeneration. Loss of ADAM17, TNF and the TNF receptor Grindelwald in pigmented glial cells of the Drosophila retina leads to age-related degene ...[more]
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