Ontology highlight
ABSTRACT:
SUBMITTER: Bauer KE
PROVIDER: S-EPMC6639396 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Bauer Karl E KE Segura Inmaculada I Gaspar Imre I Scheuss Volker V Illig Christin C Ammer Georg G Hutten Saskia S Basyuk Eugénia E Fernández-Moya Sandra M SM Ehses Janina J Bertrand Edouard E Kiebler Michael A MA
Nature communications 20190718 1
mRNA transport restricts translation to specific subcellular locations, which is the basis for many cellular functions. However, the precise process of mRNA sorting to synapses in neurons remains elusive. Here we use Rgs4 mRNA to investigate 3'-UTR-dependent transport by MS2 live-cell imaging. The majority of observed RNA granules display 3'-UTR independent bidirectional transport in dendrites. Importantly, the Rgs4 3'-UTR causes an anterograde transport bias, which requires the Staufen2 protein ...[more]