Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates.
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ABSTRACT:
SUBMITTER: Furler RL
PROVIDER: S-EPMC6640090 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates.
Furler Robert L RL Ali Ayub A Yang Otto O OO Nixon Douglas F DF
Virus genes 20190515 4
Almost 80% of viral transcripts during early HIV-1 infection encode the Nef protein, which has been implicated in altering expression of a number of genes. In this study, we infected primary human CD4<sup>+</sup> T cells with pseudotyped Nef-containing or Nef-deleted (Δ-nef) NL4-3 virus and used RNA-Sequencing (RNA-Seq) for transcriptomic analysis. Our results showed that the interferon response, IL-15 and JAK/STAT signaling, as well as genes involved in metabolism, apoptosis, cell cycle regulat ...[more]
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2016-12-06 | GSE76793 | GEO
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