Ontology highlight
ABSTRACT:
SUBMITTER: Vargas DA
PROVIDER: S-EPMC6640091 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190624 30
2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive molecules. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochemically rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling th ...[more]