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Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold.


ABSTRACT: Prenylation of aromatic compounds is a key tailoring reaction in biosynthesis of bioactive indole-diterpenes. Here, we identify NodD1 as the enzyme responsible for the bisprenylation of nodulisporic acid F. This prenyltransferase showed a preference for its natural indole-diterpene substrate whereas other related enzymes were not able to catalyse this conversion.

SUBMITTER: Van de Bittner KC 

PROVIDER: S-EPMC6640557 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Nodulisporic acid E biosynthesis: <i>in vivo</i> characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold.

Van de Bittner Kyle C KC   Cameron Rosannah C RC   Bustamante Leyla Y LY   Bundela Rudranuj R   Kessans Sarah A SA   Vorster Jan J   Nicholson Matthew J MJ   Parker Emily J EJ  

MedChemComm 20190527 7


Prenylation of aromatic compounds is a key tailoring reaction in biosynthesis of bioactive indole-diterpenes. Here, we identify NodD1 as the enzyme responsible for the bisprenylation of nodulisporic acid F. This prenyltransferase showed a preference for its natural indole-diterpene substrate whereas other related enzymes were not able to catalyse this conversion. ...[more]

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