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Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues.

ABSTRACT: The synthesis of two stable phomopsolide natural products (D and E) and two analogues is presented. The cytotoxicities of these four compounds are surveyed and compared across a panel of NCI-cancer cell lines. This analysis found moderate cytotoxicities (2-50 ?M) for the majority of the cell lines with phomopsolide D being more active than phomopsolide E and the 7-oxa analogue being commensurately more active than the 7-aza analogue.

SUBMITTER: Aljahdali AZ

PROVIDER: S-EPMC6640558 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues.

Aljahdali Alhanouf Z AZ Freedman Seth A SA Scott Jana J Li Miaosheng M O'Doherty George A GA

MedChemComm 20190508 7

The synthesis of two stable phomopsolide natural products (D and E) and two analogues is presented. The cytotoxicities of these four compounds are surveyed and compared across a panel of NCI-cancer cell lines. This analysis found moderate cytotoxicities (2-50 μM) for the majority of the cell lines with phomopsolide D being more active than phomopsolide E and the 7-oxa analogue being commensurately more active than the 7-aza analogue. ...[more]

PMID: 31391894

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