Ontology highlight
ABSTRACT:
SUBMITTER: Spiegelman NA
PROVIDER: S-EPMC6402572 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Spiegelman Nicole A NA Price Ian R IR Jing Hui H Wang Miao M Yang Min M Cao Ji J Hong Jun Young JY Zhang Xiaoyu X Aramsangtienchai Pornpun P Sadhukhan Sushabhan S Lin Hening H
ChemMedChem 20180813 18
Sirtuin inhibitors have attracted much interest due to the involvement of sirtuins in various biological processes. Several SIRT2-selective inhibitors have been developed, and some exhibit anticancer activities. To facilitate the choice of inhibitors in future studies and the development of better inhibitors, we directly compared several reported SIRT2-selective inhibitors: AGK2, SirReal2, Tenovin-6, and TM. In vitro, TM is the most potent and selective inhibitor, and only TM could inhibit the d ...[more]