Ontology highlight
ABSTRACT:
SUBMITTER: Hoydahl LS
PROVIDER: S-EPMC6640717 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Høydahl Lene Støkken LS Frick Rahel R Sandlie Inger I Løset Geir Åge GÅ
Antibodies (Basel, Switzerland) 20190509 2
Monoclonal antibodies (mAbs) are valuable as research reagents, in diagnosis and in therapy. Their high specificity, the ease in production, favorable biophysical properties and the opportunity to engineer different properties make mAbs a versatile class of biologics. mAbs targeting peptide-major histocompatibility molecule (pMHC) complexes are often referred to as "TCR-like" mAbs, as pMHC complexes are generally recognized by T-cell receptors (TCRs). Presentation of self- and non-self-derived p ...[more]