Ontology highlight
ABSTRACT:
SUBMITTER: Renteria-Gomez A
PROVIDER: S-EPMC6640813 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
ACS omega 20161116 5
A series of fifteen 2-tetrazolylmethyl-isoindolin-1-one linked-type bis-heterocycles were synthesized in 10-76% yields under mild conditions via a one-pot Ugi-azide/(N<i>-</i>acylation/<i>exo</i>-Diels-Alder)/dehydration process from furan-2-ylmethanamine, aldehydes, isocyanides, azidotrimethylsilane, and maleic anhydride. Density functional theory calculations were performed using the polarizable continuum model (toluene)-M06-2X-D3/6-311+G(d)//M06-2X-D3/6-31G(d) level of theory to obtain the fu ...[more]