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Synthesis of 3-CF₂-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones.

ABSTRACT: A general and efficient visible-light-induced CF₂ radical-based cascade reaction of o-hydroxyaryl enaminones has been described. This protocol afforded the corresponding functionalized 3-CF₂-containing chromones in generally good yields under mild reaction conditions. The use of NaHSO₃, which has both basicity and reducibility, efficiently suppressed the formation of two byproducts, 4H-chromen-4-one and 3-bromo-4H-chromen-4-one.

SUBMITTER: Gao H

PROVIDER: S-EPMC6641644 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Synthesis of 3-CF2-Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o-Hydroxyaryl Enaminones.

Gao Huang H Hu Bei B Dong Wuheng W Gao Xiaoshuang X Jiang Lili L Xie Xiaomin X Zhang Zhaoguo Z

ACS omega 20170705 7

A general and efficient visible-light-induced CF2 radical-based cascade reaction of o-hydroxyaryl enaminones has been described. This protocol afforded the corresponding functionalized 3-CF2-containing chromones in generally good yields under mild reaction conditions. The use of NaHSO3, which has both basicity and reducibility, efficiently suppressed the formation of two byproducts, 4H-chromen-4-one and 3-bromo-4H-chromen-4-one. ...[more]

PMID: 31457645

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