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Highly Efficient Method for Suzuki Reactions in Aqueous Media.

ABSTRACT: Herein, we report the crystal structure and characterization of mono-6-(l-aminopropanol)-deoxy-?-cyclodextrin (L _n @?-CD). A highly efficient, in situ generated catalyst, PdCl₂(L _n @?-CD), was synthesized for palladium-catalyzed cross-coupling reactions under mild reaction conditions, and the use of this catalyst in Suzuki cross-couplings was investigated. Low palladium loadings of 0.01 mol % PdCl₂(L _n @?-CD) (Pd accounted for approximately 8.4% of the catalyst by mass) were found to be highly efficient for Suzuki cross-couplings in water and afforded the corresponding biaryl compounds in excellent yields. The catalyst can be recycled and reused.

SUBMITTER: Zhou X

PROVIDER: S-EPMC6641778 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Highly Efficient Method for Suzuki Reactions in Aqueous Media.

Zhou Xinglong X Guo Xuming X Jian Fangfang F Wei Gang G

ACS omega 20180424 4

Herein, we report the crystal structure and characterization of mono-6-(l-aminopropanol)-deoxy-β-cyclodextrin (L n @β-CD). A highly efficient, in situ generated catalyst, PdCl2(L n @β-CD), was synthesized for palladium-catalyzed cross-coupling reactions under mild reaction conditions, and the use of this catalyst in Suzuki cross-couplings was investigated. Low palladium loadings of 0.01 mol % PdCl2(L n @β-CD) (Pd account ...[more]

PMID: 31458668

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