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Direct Synthesis of Chalcones from Anilides with Phenyl Vinyl Ketones by Oxidative Coupling Through C-H Bond Activation.

ABSTRACT: A novel approach for synthesizing chalcones by Pd-catalyzed oxidative coupling is described. This is the first report of the efficient coupling reaction of acetanilides with phenyl vinyl ketones under mild conditions. Selective C-H activation occurred next to the acetamide group to afford 2-aminochalcone derivatives. The reaction proceeded under an O2 atmosphere without any chemical co-oxidants.

SUBMITTER: Maegawa T

PROVIDER: S-EPMC6641892 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Direct Synthesis of Chalcones from Anilides with Phenyl Vinyl Ketones by Oxidative Coupling Through C-H Bond Activation.

Maegawa Tomohiro T Mizui Ryota R Urasaki Miki M Fujimura Kazuma K Nakamura Akira A Miki Yasuyoshi Y

ACS omega 20180518 5

A novel approach for synthesizing chalcones by Pd-catalyzed oxidative coupling is described. This is the first report of the efficient coupling reaction of acetanilides with phenyl vinyl ketones under mild conditions. Selective C-H activation occurred next to the acetamide group to afford 2-aminochalcone derivatives. The reaction proceeded under an O<sub>2</sub> atmosphere without any chemical co-oxidants. ...[more]

PMID: 31458746

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