Ontology highlight
ABSTRACT:
SUBMITTER: Thimmarayaperumal S
PROVIDER: S-EPMC6641896 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
ACS omega 20170824 8
A highly efficient domino protocol has been developed for the synthesis of 6-aryl-4-(methylthio/amine-1-yl)-2-oxo-2<i>H</i>-pyran-3-carbonitriles and 4-aryl-2-(amine-1-yl)-5,6,7,8-tetrahydronaphthalene-1-carbonitriles from simple and readily available α-aroylketene dithioacetals, malononitrile, secondary amines, and cyclohexanone. This elegant domino process involved consecutive addition-elimination, intramolecular cyclization, and ring opening and closing sequences. Notably, in situ generated 2 ...[more]