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Synthesis of (-)-Indolizidine 167B based on domino hydroformylation/cyclization reactions.

ABSTRACT: The synthesis of (-)-Indolizidine 167B has been achieved from optically active (R)-3-(pyrrol-1-yl)hex-1-ene. The key step is a highly regioselective hydroformylation reaction and a one-pot intramolecular cyclization providing a general approach to the indolizine nucleus.

SUBMITTER: Guazzelli G

PROVIDER: S-EPMC2241606 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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Synthesis of (-)-Indolizidine 167B based on domino hydroformylation/cyclization reactions.

Guazzelli Giuditta G Lazzaroni Raffaello R Settambolo Roberta R

Beilstein journal of organic chemistry 20080115

The synthesis of (-)-Indolizidine 167B has been achieved from optically active (R)-3-(pyrrol-1-yl)hex-1-ene. The key step is a highly regioselective hydroformylation reaction and a one-pot intramolecular cyclization providing a general approach to the indolizine nucleus. ...[more]

PMID: 18197967

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