Ontology highlight
ABSTRACT:
SUBMITTER: Zhou C
PROVIDER: S-EPMC6642083 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zhou Chen C Yan Ling L Zhang Wen-Hui WH Liu Zhu Z
Nature communications 20190719 1
The C-terminus of α-tubulin undergoes a detyrosination/tyrosination cycle and dysregulation of this cycle is associated with cancer and other diseases. The molecular mechanisms of tubulin tyrosination are well studied, however it has remained unknown how tyrosine is cleaved from the tubulin tail. Here, we report the crystal structure of the long-sought detyrosination enzyme, the VASH2/SVBP heterodimer at 2.2 Å resolution and the structure of the tail/VASH2/SVBP complex at 2.5 Å resolution. VASH2 ...[more]