Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC6927241 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wang Rui R Yu Ruoxuan R Zhu Cheng C Lin Hai-Yan HY Lu Xiaoyin X Wang Hongmei H
Journal of molecular cell biology 20191201 11
Human trophoblast syncytialization is one of the most important yet least understood events during placental development. In this study, we found that detyrosinated α-tubulin (detyr-α-tub), which is negatively regulated by tubulin tyrosine ligase (TTL), was elevated during human placental cytotrophoblast fusion. Correspondingly, relatively high expression of TTL protein was observed in first-trimester human placental cytotrophoblast cells, but fusing trophoblast cells exhibited much lower levels ...[more]