Ontology highlight
ABSTRACT:
SUBMITTER: Wang XD
PROVIDER: S-EPMC6642156 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Wang Xu-Dong XD Hu Rongkuan R Ding Qing Q Savage Trisha K TK Huffman Kenneth E KE Williams Noelle N Cobb Melanie H MH Minna John D JD Johnson Jane E JE Yu Yonghao Y
Nature communications 20190719 1
Pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC), is a particularly aggressive malignancy. The lineage-specific transcription factors Achaete-scute homolog 1 (ASCL1), NEUROD1 and POU2F3 have been reported to identify the different subtypes of pulmonary NE cancers. Using a large-scale mass spectrometric approach, here we perform quantitative secretome analysis in 13 cell lines that signify the different NE lung cancer subtypes. We quantify 1,626 proteins and identify ...[more]