Subtype-specific characterization of breast cancer invasion using a microfluidic tumor platform.
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ABSTRACT:
SUBMITTER: Moon HR
PROVIDER: S-EPMC7297326 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Subtype-specific characterization of breast cancer invasion using a microfluidic tumor platform.
Moon Hye-Ran HR Ospina-Muñoz Natalia N Noe-Kim Victoria V Yang Yi Y Elzey Bennett D BD Konieczny Stephen F SF Han Bumsoo B
PloS one 20200616 6
Understanding progression of breast cancers to invasive ductal carcinoma (IDC) can significantly improve breast cancer treatments. However, it is still difficult to identify genetic signatures and the role of tumor microenvironment to distinguish pathological stages of pre-invasive lesion and IDC. Presence of multiple subtypes of breast cancers makes the assessment more challenging. In this study, an in-vitro microfluidic assay was developed to quantitatively assess the subtype-specific invasion ...[more]
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