Ontology highlight
ABSTRACT:
SUBMITTER: Desalegn G
PROVIDER: S-EPMC6642215 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Desalegn Girmay G Pabst Oliver O
Nature communications 20190719 1
Bone marrow-derived circulating monocytes contribute to the replenishment and maintenance of the intestinal macrophage population. Intestinal monocytes undergo context-dependent phenotypic and functional adaptations to either maintain local immune balance or support intestinal inflammation. Here we use monocyte adoptive transfer to dissect the dynamics of monocyte-to-macrophage differentiation in normal and inflamed small intestine. We find that during homeostasis CCR2 and β7-integrin mediate co ...[more]