Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC6642228 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Wang Guangliang G Zhang Guoqiang G Li Zhuyun Z Fawcett Caroline H CH Coble Matthew M Sosa Maria X MX Tsai Tingwei T Malesky Kimberly K Thibodeaux Stefan J SJ Zhu Peixin P Glass David J DJ Fishman Mark C MC
iScience 20190704
Dopamine transporter (SLC6A3) deficiency causes infantile Parkinson disease, for which there is no effective therapy. We have explored the effects of genetically deleting SLC6A3 in zebrafish. Unlike the wild-type, slc6a3-/- fish hover near the tank bottom, with a repetitive digging-like behavior. slc6a3-/- fish manifest pruning and cellular loss of particular tyrosine hydroxylase-immunoreactive neurons in the midbrain. Clozapine, an effective therapeutic for treatment-resistant schizophrenia, re ...[more]