Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells.
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ABSTRACT:
SUBMITTER: Zirin J
PROVIDER: S-EPMC6642371 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells.
Zirin Jonathan J Ni Xiaochun X Sack Laura M LM Yang-Zhou Donghui D Hu Yanhui Y Brathwaite Roderick R Bulyk Martha L ML Elledge Stephen J SJ Perrimon Norbert N
Proceedings of the National Academy of Sciences of the United States of America 20190701 29
Aberrant MYC oncogene activation is one of the most prevalent characteristics of cancer. By overlapping datasets of <i>Drosophila</i> genes that are insulin-responsive and also regulate nucleolus size, we enriched for Myc target genes required for cellular biosynthesis. Among these, we identified the aminoacyl tRNA synthetases (aaRSs) as essential mediators of Myc growth control in <i>Drosophila</i> and found that their pharmacologic inhibition is sufficient to kill MYC-overexpressing human cell ...[more]
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