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Base-Catalyzed 1,6-Conjugate Addition of Nitroalkanes to p-Quinone Methides under Continuous Flow.

ABSTRACT: A mild base-catalyzed protocol for the synthesis of substituted nitroalkane derivatives has been developed under continuous flow using a microreaction technique. This transformation basically involves the 1,6-conjugate addition of nitroalkanes to p-quinone methides, leading to the substituted nitroalkanes in good to excellent yields.

SUBMITTER: Pandey R 

PROVIDER: S-EPMC6644449 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Base-Catalyzed 1,6-Conjugate Addition of Nitroalkanes to <i>p</i>-Quinone Methides under Continuous Flow.

Pandey Rajat R   Anand Ramasamy Vijaya RV  

ACS omega 20181024 10

A mild base-catalyzed protocol for the synthesis of substituted nitroalkane derivatives has been developed under continuous flow using a microreaction technique. This transformation basically involves the 1,6-conjugate addition of nitroalkanes to <i>p</i>-quinone methides, leading to the substituted nitroalkanes in good to excellent yields. ...[more]

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