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Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation of para-Quinone Methides: Facile Access to Diarylmethyl Sulfones.

ABSTRACT: An efficient, catalyst-free strategy to construct diarylmethyl sulfones via 1,6-conjugate addition/aromatization/sulfonylation reaction of para-quinone methides with sulfonyl hydrazides under mild and environmentally benign conditions has been developed. The established protocol provided a highly chemo- and regioselectivity synthesis of a diverse array of novel diarylmethyl sulfones with excellent yields, and the reaction could be scaled up.

SUBMITTER: Liu T 

PROVIDER: S-EPMC6641250 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation of <i>para</i>-Quinone Methides: Facile Access to Diarylmethyl Sulfones.

Liu Teng T   Liu Jianjun J   Xia Shubiao S   Meng Jie J   Shen Xianfu X   Zhu Xiufang X   Chen Wenchang W   Sun Chengke C   Cheng Feixiang F  

ACS omega 20180202 2

An efficient, catalyst-free strategy to construct diarylmethyl sulfones via 1,6-conjugate addition/aromatization/sulfonylation reaction of <i>para</i>-quinone methides with sulfonyl hydrazides under mild and environmentally benign conditions has been developed. The established protocol provided a highly chemo- and regioselectivity synthesis of a diverse array of novel diarylmethyl sulfones with excellent yields, and the reaction could be scaled up. ...[more]

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